Acetic Acid → HCID 178433040, compound

Participants

Reaction Conditions

Reaction Steps

N-(6-{6-(Ethyloxy)-5-[(phenylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)-2-methyl-1,3-thiazole-4-carboxamide (24 mg) was weighed to a microwave vial and acetic acid (0.25 ml) and concentrated HCl (0.25 ml) were added. The reaction was heated under microwave irradiation for 10 min at 100° C. The reaction was cooled to RT and then heated again under microwave irradiation for 10 min at 100° C. Water was added to the reaction and the resultant precipitate was collected by filtration. The precipitate was dissolved into MeOH:DCM then evaporated to dryness. The residue was then dissolved in DMSO:MeOH (0.8 ml, 1:1, v/v) and purified by MDAP (method F) to give the title compound (6.5 mg).

Provenance & Evidence