HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 72325456, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 3-(Piperidin-4-yl)-3,4-dihydroquinazolin-2(1H)-one | HCID 11042597 | — |
| Reactant | 2-(3-Isopentyl-4-oxo-2-phenylthiazolidin-5-ylidene)acetic acid | HCID 72325437 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 72325456 | HCID 72325456 | — |
Reaction Steps
To a solution of 2-(3-isopentyl-4-oxo-2-phenylthiazolidin-5-ylidene)acetic acid (11 mg, 0.036 mmol), 3,4-Dihydro-3-(piperidin-4-yl)quinazolin-2(1H)-one.TFA (18 mg, 0.054 mmol) and DiPEA (22 ul, 0.14 mmol) in DMF (0.2 ml) was added HATU (16 mg, 0.043 mmol) and the reaction mixture was stirred at RT for 16 hours. Purification by preparative reverse phase HPLC using 10%-99% CH3CN (0.035% TFA)/H2O (0.05% TFA) gave the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163737B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-01463a4452de49d098002912617a2361 |
| Source note | uspto-grants-2012_04 |