HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl 3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate → Spiro[indene-1,4'-piperidin]-3(2H)-one hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl 3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate | HCID 18673579 | — |
| Reactant | Hydrochloride methanol | HCID 21893726 | — |
| Product | Spiro[indene-1,4'-piperidin]-3(2H)-one hydrochloride | HCID 18673582 | 97.6% |
Reaction Steps
The mixture of tert-butyl 3-oxo-2,3-dihydrospiro[indene-1,4′-piperidine]-1′-carboxylate (20 g, 66.4 mmol) and MeOH/HCl (2.5 mol/L, 100 mL) were stirred overnight. After evaporation the residue was washed by petroleum ether to provide spiro[indene-1,4′-piperidin]-3(2H)-one hydrochloride (15.4 g, 97.6%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163737B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-258c4128e894459f91488adaf8ed9b2a |
| Source note | uspto-grants-2012_04 |