(s)-2-Mercaptosuccinic acid → 2-((5S)-2-(2-(2-(piperidin-1-yl)ethylamino)-3-fluorophenyl)-3-(3,3-dimethylbutyl)-4-oxothiazolidin-5-yl)acetic acid

Participants

Reaction Steps

2-((E)-(3,3-dimethylbutylimino)methyl)-6-fluoro-N-(2-(piperidin-1-yl)ethyl)benzenamine (457 mg, 1.370 mmol) and (S)-2-mercaptosuccinic acid (224 mg, 1.492 mmol) were stirred in toluene (14 mL) at 80° C. for 24 hours. The solvent was removed on a rotary evaporator under high vacuum at 35° C. Crude 2-((5S)-2-(2-(2-(piperidin-1-yl)ethylamino)-3-fluorophenyl)-3-(3,3-dimethylbutyl)-4-oxothiazolidin-5-yl)acetic acid was obtained as a brown foam and carried on to the next reaction.

Provenance & Evidence