HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2-(2-(Dimethylamino)ethylamino)-3-fluorophenyl)methanol → 2-(2-(Dimethylamino)ethylamino)-3-fluorobenzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2-(2-(Dimethylamino)ethylamino)-3-fluorophenyl)methanol | HCID 57774489 | — |
| Catalyst | Manganese dioxide | HCID 14801 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-(2-(Dimethylamino)ethylamino)-3-fluorobenzaldehyde | HCID 57774420 | — |
Reaction Steps
(2-(2-(dimethylamino)ethylamino)-3-fluorophenyl)methanol (536 mg, 2.525 mmol) and MnO2 (878.1 mg, 174.7 μL, 10.10 mmol) were heated to reflux in toluene (13 mL) overnight. The suspension was filtered through Celite with CH2Cl2 and concentrated on a rotary evaporator. The crude product was purified on 12 g Redisep ISCO column eluting with 4-55% EtOAc/Hexanes over 30 CV. 2-(2-(Dimethylamino)ethylamino)-3-fluorobenzaldehyde was identified by 1H-NMR and carried on to next reaction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163737B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-05d0d4d99adb4fb5b23619958368f273 |
| Source note | uspto-grants-2012_04 |