反应详情

2-(2-(Dimethylamino)ethylamino)-3-fluorobenzaldehyde (157 mg, 0.7467 mmol) and 3,3-dimethylbutan-1-amine (150 μL, 1.115 mmol) were stirred at RT in toluene (5 mL) with 4 Å MS overnight. The suspension was filtered and volatiles removed on a rotary evaporator at 40° C. 1H-NMR was consistent with 2-((E)-(3,3-dimethylbutylimino)methyl)-N-(2-(dimethylamino)ethyl)-6-fluorobenzenamine (175 mg). The crude product was carried on to next reaction.

1. filtrationThe suspension was filtered
2. customvolatiles removed on a rotary evaporator at 40° C
3. customThe crude product was carried on to next reaction