3,3-Dimethylbutylamine → HCID 178444760, compound

Participants

Reaction Steps

To a solution of tert-butyl 4-(2-formylphenyl)piperidine-1-carboxylate (229 mg, 0.79 mmol) in toluene (4 mL) was added 3,3 dimethylbutylamine (88.09 mg, 117.1 μL, 0.8705 mmol) and 4 Å molecular sieves. The resulting suspension was stirred at rt overnight. Filtered out molecular sieves and concentrated the mixture with a flow of N2 to give 282 mg of tert-butyl 4-(2-((E)-(3,3-dimethylbutylimino)methyl)phenyl)piperidine-1-carboxylate as an thick off-white oil which was used without further purification for the next step.

Provenance & Evidence