tert-butyl 4-(2-(N-methoxy-N-methylcarbamoyl)-6-fluorophenyl)-5,6-dihydropyridine-1(2H)-carboxylate → tert-Butyl 4-(2-(N-methoxy-N-methylcarbamoyl)-6-fluorophenyl)piperidine-1-carboxylate

Participants

Reaction Steps

A solution of tert-butyl 4-(2-(N-methoxy-N-methylcarbamoyl)-6-fluorophenyl)-5,6-dihydropyridine-1(2H)-carboxylate (450 mg, 1.235 mmol) and PtO2 (180 mg) in EtOH (19 mL) was shaken in a Parr flask for 1 h15 under 51 psi of H2. The reaction was monitored by LC/MS. Unreacted SM was detected, so another 150 mg of PtO2 (total: 450 mg, 30 wt %) was then added and the mixture was hydrogenated under 50 psi for another 3 h. Mostly desired product was detected after 4 h by LC/MS (Rt=2.83 min). The catalyst was filtered off and the solution was concentrated in vacuo to yield 435 mg of tert-butyl 4-(2-(N-methoxy-N-methylcarbamoyl)-6-fluorophenyl)piperidine-1-carboxylate as a clear thick oil which was used as is for the next step. LC/MS ES+1: 367.38.

Provenance & Evidence