HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1695963Generated: October 25, 2026
Ethanol → 4-(3-Isoxazol-5-yl-5-oxo-2,5-dihydro-pyrazol-1-yl)-N-(1,2,2,6,6-pentamethyl-piperidin-4-yl)-benzamide
https://huagongshe.com/reaction/1695963
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | 4-Hydrazino-N-(1,2,2,6,6-pentamethyl-piperidin-4-yl)-benzamide | HCID 59515576 | — |
| Reactant | 3-Isoxazol-5-yl-3-oxo-propionic acid ethyl ester | HCID 59515581 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 4-(3-Isoxazol-5-yl-5-oxo-2,5-dihydro-pyrazol-1-yl)-N-(1,2,2,6,6-pentamethyl-piperidin-4-yl)-benzamide | HCID 59515579 | — |
Reaction Steps
3-Isoxazol-5-yl-3-oxo-propionic acid ethyl ester (49 mg) and 4-Hydrazino-N-(1,2,2,6,6-pentamethyl-piperidin-4-yl)-benzamide (93 mg) were dissolved into ethanol (2.5 ml) and acetic acid (0.3 ml) and the solution stirred at 65° C. for 2 h. Concentration in vacuo and purification by HPLC gave the expected product. LC/MS: main peak is product (m/z: 424.3)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08163757B2 |
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| Source dataset | uspto-grants-2012_04 |
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| ORD ID | ord-b749f24f24fe4fcba056b5e8b41063bc |
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| Source note | uspto-grants-2012_04 |
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