HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-(furan-2-yl)-2-methyl-3-oxopropanoate → 4-(3-Furan-2-yl-4-methyl-5-oxo-2,5-dihydro-pyrazol-1-yl)-N-(1,2,2,6,6-pentamethyl-piperidin-4-yl)-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-(furan-2-yl)-2-methyl-3-oxopropanoate | HCID 12143105 | — |
| Reactant | 4-Hydrazino-N-(1,2,2,6,6-pentamethyl-piperidin-4-yl)-benzamide | HCID 59515576 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 4-(3-Furan-2-yl-4-methyl-5-oxo-2,5-dihydro-pyrazol-1-yl)-N-(1,2,2,6,6-pentamethyl-piperidin-4-yl)-benzamide | HCID 59515578 | — |
Reaction Steps
3-furan-2-yl-2-methyl-3-oxo-propionic acid ethyl ester (49 mg) and 4-Hydrazino-N-(1,2,2,6,6-pentamethyl-piperidin-4-yl)-benzamide (85 mg) in 0.5 ml of acetic acid were heated up at 65° C. for 2 h. Concentration in vacuo and purification by HPLC gave the expected product. MH+=437.3
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163757B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-ba31943c0c864cfbb1fecfa0e6185015 |
| Source note | uspto-grants-2012_04 |