HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium ethoxide → 3-Furan-2-yl-2,2-dimethyl-3-oxo-propionic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Reactant | Ethyl 3-(furan-2-yl)-2-methyl-3-oxopropanoate | HCID 12143105 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-Furan-2-yl-2,2-dimethyl-3-oxo-propionic acid ethyl ester | HCID 59515582 | — |
Reaction Steps
3-furan-2-yl-2-methyl-3-oxo-propionic acid ethyl ester (49 mg) was added sodium ethoxide (0.22 ml) and 0.5 ml ethanol. A solid precipitates. The solution was stirred at room temperature for 1 h, iodomethane was added and the suspension stirred at room temperature for 3 h. Concentration in vacuo and purification by HPLC gave the expected product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163757B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-78b175d68b0a49babe6b502b4464e01f |
| Source note | uspto-grants-2012_04 |