HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1695999Generated: November 2, 2026
Methanol → Methyl 4-benzyl-3-methyl-5-oxomorpholine-3-carboxylate
https://huagongshe.com/reaction/1695999
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 4-Benzyl-3-methyl-5-oxomorpholine-3-carboxylic acid | HCID 67269211 | — |
| Product | Methyl 4-benzyl-3-methyl-5-oxomorpholine-3-carboxylate | HCID 67268468 | — |
Reaction Steps
Dissolve 4-benzyl-3-methyl-5-oxomorpholine-3-carboxylic acid (1 eq) in MeOH (10 volumes) and stir. Add sulfuric acid (3 eq) dropwise. Heat at 50° C. for 24 hours. Cool to room temperature and concentrate. Add EtOAc (25 volumes) wash with water (7 volumes), followed by saturated aqueous NaHCO3 (5 volumes), and then water (7 volumes). Dry the EtOAc layer and concentrated to give methyl 4-benzyl-3-methyl-5-oxomorpholine-3-carboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08163755B2 |
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| Source dataset | uspto-grants-2012_04 |
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| ORD ID | ord-13a8524c404346c58035581ab6fd96fb |
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| Source note | uspto-grants-2012_04 |
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