Dihydrouracil → HCID 178419787, compound

HRID 1696069Notes

Reaction equation

HRID 1696069 reaction equation
[NH:1]1[CH2:6][CH2:5][C:4](=O)[NH:3][C:2]1=O.C([N:16]1C=C[N:18]=[C:17]1CCN)C1C=CC=CC=1>>[NH:1]1[CH:6]=[C:5]2[C:4]([N:16]=[CH:17][NH:18]2)=[N:3][CH2:2]1

Participants

3

Reactant 2

HCID 649DihydrouracilHCID 174854142-(1-benzyl-1H-imidazol-2-yl)ethan-1-amine

Product 1

HCID 178419787HCID 178419787, compound

Procedure

Treatment of imidazole 1 with n-BuLi, followed by an alkylation reaction, and a deprotection reaction with TFA affords 2-(1-methyl-1H-imidazol-2-yl)ethanamine. Amine 3 can be coupled with dihydropurine 4 to give compound 5.

Sources & evidence

ORD record
ord-9c7bfad98b254e4598d4d2b1a5dfde01
Source dataset
uspto-grants-2012_04
Patent number
US08163761B2

Reaction notes

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