HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1696123Generated: October 26, 2026
Dabco → N-(pyrimidin-4-yl)-4-(1-(2,2,2-trifluoroacetyl)piperidin-4-yl)benzenesulfonamide
https://huagongshe.com/reaction/1696123
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dabco | HCID 9237 | — |
| Reactant | 4-Aminopyrimidine | HCID 68958 | — |
| Reactant | 4-(1-(2,2,2-Trifluoroacetyl)piperidin-4-yl)benzene-1-sulfonyl chloride | HCID 17973478 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | N-(pyrimidin-4-yl)-4-(1-(2,2,2-trifluoroacetyl)piperidin-4-yl)benzenesulfonamide | HCID 59465873 | 36.6% |
Reaction Steps
Prepared using general procedure 15, method B. Prepared using a mixture of 4-(1-(2,2,2-trifluoroacetyl)piperidin-4-yl)benzene-1-sulfonyl chloride (2.0 g, 5.6 mmol), 4-aminopyrimidine (535 mg, 5.6 mmol), DABCO (3.1 g, 28.0 mmol) and acetonitrile (10 mL). The reaction mixture was heated at 40° C. for 6 h. Purification via silica gel chromatography using 5% MeOH in CH2Cl2 gave N-(pyrimidin-4-yl)-4-(1-(2,2,2-trifluoroacetyl)piperidin-4-yl)benzenesulfonamide (850 mg, 36%). LC/MS (10%-99% CH3CN (0.035% TFA)/H2O (0.05% TFA)), m/z: M+1 obs=415.3; tR=2.57 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08163720B2 |
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| Source dataset | uspto-grants-2012_04 |
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| ORD ID | ord-5bcf952db2b642029ee57ef54df2cda6 |
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| Source note | uspto-grants-2012_04 |
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