HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → ((1S,3R)-3-aminocyclohexyl)methanol hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 83823767 | HCID 83823767 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | ((1S,3R)-3-aminocyclohexyl)methanol hydrochloride | HCID 67278446 | — |
Reaction Steps
To a solution of tert-butyl[cis-3-(hydroxymethyl)cyclohexyl]carbamate (311 mg) in EtOAc (3.1 ml) was added 4M HCl in EtOAc which was stirred at ambient temperature for 1 hour. Resulting precipitates were collected by filtration and washed with diisopropyl ether to give [cis-3-aminocyclohexyl]methanol hydrochloride (236 mg) as a white powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163767B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-bcfeb085017d4d2ca7c36e2e73060efe |
| Source note | uspto-grants-2012_04 |