Cyanuric chloride → HCID 67277576, compound

Participants

Reaction Steps

To a solution of rel-(1R,2S)-2-(2-oxo-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(2H)-yl)cyclohexanecarboxamide (14 mg) in N,N-dimethylformamide (140 μl) was added 2,4,6-trichloro-1,3,5-triazine (8.63 mg) at 0° C. The reaction mixture was stirred at ambient temperature overnight. The solution was diluted with water and extracted with EtOAc/tetrahydrofuran. The organic layer was dried over MgSO4 and concentrated in vacuo. The residual solid was washed with diisopropylethylether to give rel-(1R,2S)-2-(2-oxo-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(2H)-yl)cyclohexanecarbo-nitrile (3 mg) as a pale brown solid.

Provenance & Evidence