Tris(hydroxymethyl)aminomethane → HCID 67278468, compound

Participants

Reaction Steps

A mixture of 1-piperidin-3-yl-3,6-dihydroimidazo[4,5-d]-pyrrolo[2,3-b]pyridin-2(1H)-one (0.030M solution in N,N-dimethylformamide, 1.00 mL), 1-hydroxybenzotriazole (4.1 mg, 0.030 mmol), 3-but-enoic acid (0.50M solution in NMP, 0.080 mL), and PS-Carbodiimide (Argonaut technologies,50 mg) was agitated at ambient temperature for 16 hours. PS-Trisamine (Argonaut technologies, 50 mg), PS-Isocyanate (50 mg) was added and the reaction agitated at ambient temperature for a further 2 hours and filtered. The filtrate was concentrated to yield 1-(1-but-3-enoylpiperidin-3-yl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2(1H)-one (9.7 mg).

Provenance & Evidence