Benzene, (3-bromopropoxy)- → 1-(2-methylcyclohexyl)-3-(3-phenoxypropyl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2(1H)-one

참여 물질

역할	이름	HCID	투입량
반응물	Benzene, (3-bromopropoxy)-	HCID 68522	—
반응물	1,2,3,5,6,7-Hexahydroimidazo[1,5-a]pyridine	HCID 14178337	—
반응물	1-(2-methylcyclohexyl)-3,6-dihydroimidazo-[4,5-d]pyrrolo[2,3-b]pyridin-2(1H)-one	HCID 67278194	—
생성물	1-(2-methylcyclohexyl)-3-(3-phenoxypropyl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2(1H)-one	HCID 67278297	—

반응 조건

온도	60 °C

반응 단계

A mixture of 1-(2-methylcyclohexyl)-3,6-dihydroimidazo-[4,5-d]pyrrolo[2,3-b]pyridin-2(1H)-one (0.030M solution in N,N-dimethylformamide, 1.00 mL), 3-bromopropyl phenyl ether (12.9 mg), 1,8-diazabicyclo[4,3,0]non-5-ene (0.013 mL), was heated at 60° C. for 16 hours. The solvent was removed in vacuo and purification by preparative high performance liquid chromatography gave 1-(2-methylcyclohexyl)-3-(3-phenoxypropyl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2(1H)-one (2.6 mg).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08163767B2
출처 데이터셋	uspto-grants-2012_04
ORD ID	ord-33800192a02e4f0e9591f937dd776101
출처 메모	uspto-grants-2012_04