HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphosgene → 4-Nitro-1H-benzo[d]imidazol-2(3H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphosgene | HCID 94429 | — |
| Reactant | 3-Nitro-1,2-phenylenediamine | HCID 4359525 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-Nitro-1H-benzo[d]imidazol-2(3H)-one | HCID 4149828 | — |
Reaction Steps
Triphosgene (56 g, 188.8 mol) was added portionwise over 15 min to a solution of 3-nitro-1,2-phenylenediamine (25.5 g, 167 mol) in CH3CN (400 mL) at 0° C. and the mixture was allowed to warm to ambient temperature after 30 min. The reaction was concentrated in vacuo, diluted with toluene (100 mL) and the solid precipitate was collected by filtration to give the title compound. MS: m/z=180 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163752B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-525421729959483d9dc8801edf302430 |
| Source note | uspto-grants-2012_04 |