HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (8-Methyl-2,7-dioxo-5,6,7,8-tetrahydro-4H-imidazo[1,5,4-fg][1,6]-benzodiazocin-1(2H)-yl)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-Butyl (8-methyl-2,7-dioxo-5,6,7,8-tetrahydro-4H-imidazo[1,5,4-fg][1,6]-benzodiazocin-1(2H)-yl)acetate | HCID 86622845 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (8-Methyl-2,7-dioxo-5,6,7,8-tetrahydro-4H-imidazo[1,5,4-fg][1,6]-benzodiazocin-1(2H)-yl)acetic acid | HCID 66636442 | — |
Reaction Steps
To a solution of tert-butyl (8-methyl-2,7-dioxo-5,6,7,8-tetrahydro-4,1-imidazo[1,5,4-fg][1,6]benzodiazocin-1(2H)-yl)acetate from Step A (45 mg, 0.13 mmol) in CH2Cl2 (6 mL) was added TFA (2 mL). After 2 h, the mixture was concentrated under reduced pressure to give the title compound. MS: m/z=290 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163752B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-220990bbc37943bc8cbefa7462edcbd6 |
| Source note | uspto-grants-2012_04 |