HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → [1-(2-Ethoxy-2-oxoethyl)-3-nitro-1H-indol-4-yl]acetic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-Butyl[1-(2-ethoxy-2-oxoethyl)-3-nitro-1H-indol-4-yl]acetate | HCID 57426201 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | [1-(2-Ethoxy-2-oxoethyl)-3-nitro-1H-indol-4-yl]acetic Acid | HCID 57426202 | — |
Reaction Steps
To a solution of tert-butyl [1-(2-ethoxy-2-oxoethyl)-3-nitro-1H-indol-4-yl]acetate from Step E (300 mg, 0.828 mmol) in CH2Cl2 (1 mL) was added TFA (0.63 mL, 8.28 mmol). The mixture was stirred at ambient temperature for 1 h then concentrated in vacuo to give the title compound. MS: m/z=307 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163752B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-6a6ea56017c945eaa2c1b74dfef2d697 |
| Source note | uspto-grants-2012_04 |