Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → Ethyl 2-(3-iodophenyl)acetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 3-Iodophenylacetic acid | HCID 3870220 | — |
| 촉매 | Sulfuric Acid | HCID 1118 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Sodium chloride; water | HCID 57417360 | — |
| 생성물 | Ethyl 2-(3-iodophenyl)acetate | HCID 57581611 | 95% |
반응 단계
A solution of 2-(3-iodophenyl)acetic acid (1.05 g, 4.0 mmol, commercially available) in EtOH (12 mL) was treated with 2 drops of concentrated sulfuric acid. The resultant solution was heated at reflux for 90 min, cooled to RT and poured into hexanes (50 mL) and EtOAc (50 mL). The organics were with saturated Na2CO3 (2×50 mL), H2O (50 mL), brine (50 mL), dried (MgSO4) and concentrated to yield ethyl 2-(3-iodophenyl)acetate (1.11 g, 95% yield). MS (ESI) m/z: 291.0 (M+H+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08163756B2 |
| 출처 데이터셋 | uspto-grants-2012_04 |
| ORD ID | ord-ac26e3c44cbb4ca8b216d2ef4de705b6 |
| 출처 메모 | uspto-grants-2012_04 |