HCID 67271937, compound → HCID 67271920, compound

Participants

Reaction Steps

A mixture of (3-nitronaphthalen-1-yl)-acetic acid ethyl ester (3 g, 11.58 mmol) and 10% Pd/C (300 mg) in EtOH (100 mL) was stirred under H2 atmosphere (45 psi) at RT overnight. The mixture was filtered over Celite® and washed with EtOH. The filtrate was concentrated to afford (3-aminonaphthalen-1-yl)-acetic acid ethyl ester, which was put to the next reaction without further purification. 1H NMR (300 MHz, DMSO-d6), δ 7.65 (d, J=8.1 Hz, 1H), 7.48 (d, J=8.1 Hz, 1H), 7.27 (t, J=8.1 Hz, 1H), 7.08 (t, J=8.1 Hz, 1H), 6.85 (s, 1H), 6.73 (s, 1H), 5.35 (s, 2H), 4.06 (d, J=7.2 Hz, 2H), 3.94 (s, 2H), 1.14 (t, J=7.2 Hz, 3H); MS (ESI) m/z: 260 (M+H+).

Provenance & Evidence