Stannous chloride dihydrate → HCID 67271016, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of (3-aminonaphthalen-1-yl)acetic acid ethyl ester (2.7 g, 11.8 mmol) in conc. HCl (20 mL) was added an aqueous solution of NaNO2 (0.9 g, 13 mmol) dropwise at 0-5° C. The resulting mixture was stirred at 0° C. for 30 min and then treated with a solution of SnCl2.2H2O (5.9 g, 26.2 mmol) in conc. HCl at such a rate that the reaction temperature never rose above 5° C. After the addition was completed, the mixture was stirred for another 2 h at RT. The precipitate was collected by filtration and washed with ethyl ether to afford (3-hydrazinonaphthalen-1-yl)-acetic acid ethyl ester hydrochloride as a brown solid (2.3 g, 80% yield).

Provenance & Evidence