HCID 86008498, compound → HCID 82048421, compound

Participants

Reaction Steps

To a suspension of 2,2,2-trifluoro-1-(5-nitroindolin-1-yl)ethanone (7.92 g, 30.4 mmol) in MeOH (100 mL) was added 10% Pd/C (0.648 g, 0.609 mmol) and the slurry was stirred under H2 (1 atm) overnight. The mixture was filtered through a pad of Celite® and the filtrate was concentrated and dried under vacuum to give 7.7 g (crude yield>100%) of 1-(5-aminoindolin-1-yl)-2,2,2-trifluoroethanone as a yellow-brown solid. 1HNMR (400 MHz, CDCl3): δ 8.00 (d, J=8.8 Hz, 1H), 6.59 (s, 1H), 6.57 (d, J=8.4 Hz, 1H), 4.23 (t, J=8.0 Hz, 2H), 3.69 (brs, 2H), 3.16 (t, J=8.2 Hz, 2H); MS (ESI) m/z: 231.0 (M+H+).

Provenance & Evidence