Pentanenitrile, 4,4-dimethyl-3-oxo- → HCID 67272323, compound

Participants

Reaction Steps

A mixture of (1H-indazol-5-yl)-hydrazine hydrochloride and 4,4-dimethyl-3-oxo-pentanenitrile (19 g, 1.05 eq) in EtOH (200 mL) was heated at reflux overnight. The reaction was concentrated and the residue purified by column chromatography to yield 3-t-butyl-1-(1H-indazol-5-yl)-1H-pyrazol-5-amine (23 g, 60% of two steps). 1H NMR (300 MHz, DMSO-d6): 8.24 (s, 1H), 8.06 (s, 1H), 7.75 (d, J=9.0 Hz, 1H), 7.45 (dd, J=9.0 Hz, 1.8 Hz, 1H), 5.7 (s, 1H), 1.31 (s, 9H). MS (ESI) m/z: 256 (M+H+).

Provenance & Evidence