Hydrochloric Acid → HCID 11856056, compound

Participants

Reaction Conditions

Reaction Steps

t-Butyl 5-(3-t-butyl-5-(3-(2,3-dichlorophenyl)ureido)-1H-pyrazol-1-yl)-1H-indazole-1-carboxylate (0.1155 g, 0.213 mmol, 1.00 eq) was dissolved in satd. HCl/EtOH. The solution was heated at 80° C. for 1 h. After cooling to RT, the reaction was concentrated to dryness and treated with 80:20 MeCN/H2O. The resulting suspension was thoroughly chilled. The solids were collected by filtration, rinsed with 80:20 MeCN/H2O, MeCN and dried on the filter to yield 1-(3-t-butyl-1-(1H-indazol-5-yl)-1H-pyrazol-5-yl)-3-(2,3-dichlorophenyl)urea (55.5 mg, 54.4% yield) as the HCl salt. 1H NMR (DMSO-d6): 9.18 (s, 1H), 8.76 (s, 1H), 8.19 (s, 1H), 8.08-8.06 (m, 1H), 7.89-7.88 (m, 1H), 7.70-7.67 (m, 1H), 7.47-7.44 (m, 1H), 7.33-7.28 (m, 2H), 6.40 (s, 1H), 1.29 (s, 9H); MS (ESI) m/z: 502.0 (M+H+), 504.0 (M+2+H+).

Provenance & Evidence