Formamide → HCID 178526462, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of formamide (7.91 g, 176 mmol) and 4-nitroanthranilic acid (4.00 g, 22.0 mmol) was warmed to 160° C. and stirred for 7 h then cooled to RT and stirred overnight. The mixture was diluted with H2O (30 mL) and stirred overnight. The brown solid was collected by filtration and dried to yield 7-nitroquinazolin-4-ol (3.62 g, 86% yield). 1H NMR (300 MHz, DMSO-d6): 8.38-8.33 (m, 2H), 8.27-8.23 (m, 2H).

Provenance & Evidence