HCID 178526462, compound → HCID 178507326, compound

Participants

Reaction Steps

A solution of 7-nitroquinazolin-4-ol (3.62 g, 18.9 mmol) with 10% Pd/C (0.25 g) in DMF (15 mL) was stirred under H2 (1 atm) for 18 h, then partially concentrated at elevated temperature, filtered warm through Celite® to remove catalyst and then concentrated to a brown solid. The solid was triturated with EtOAc (50 mL), filtered, dried, redissolved in DMF (25 mL), treated with 10% Pd/C (0.25 g) and stirred overnight under an H2 atmosphere. The mixture was filtered free of catalyst and the filtrate evaporated at reduced pressure to yield a brown solid which was triturated with EtOAc (50 mL) and filtered to yield 7-aminoquinazolin-4-ol (2.27 g, 74% yield). MS (ESI) m/e (M+H+) 162.3.

Provenance & Evidence