1,2-Dichloro-3-isocyanatobenzene → HCID 135972973, compound

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Reaction Steps

Using general method A, 7-(5-amino-3-t-butyl-1H-pyrazol-1-yl)quinazolin-4(3H)-one (120 mg, 0.424 mmol) and 2,3-dichlorophenylisocyanate (79 mg, 0.487 mmol) were combined to yield 1-(3-t-butyl-1-(4-oxo-3,4-dihydroquinazolin-7-yl)-1H-pyrazol-5-yl)-3-(2,3-dichlorophenyl)urea (102 mg, 51% yield) as a white solid. 1H NMR (300 MHz, DMSO-d6): 9.41 (s, 1H), 8.79 (s, 1H), 8.25-8.23 (s, 1H), 8.16 (s, 1H), 8.08-8.02 (m, 1H), 7.82-7.75 (m, 2H), 7.32-7.30 (m, 2H), 6.46 (s, 1H), 1.30 (s, 9H). MS (ESI) m/e (M+H+) 471.0.

Provenance & Evidence