Formamide → 6-Nitro-3,4-dihydroquinazolin-4-one

Participants

Reaction Conditions

Reaction Steps

A mixture of formamide (14 g, 0.3 mol) and 2-amino-5-nitrobenzoic acid (9.1 g, 0.05 mol) was heated at 155° C. for 7 h, cooled to RT and stirred overnight. The mixture was diluted with H2O (30 mL) and filtered. The resultant brown solid was dissolved in i-PrOH (300 mL), warmed to reflux, cooled to RT and filtered and dried to yield 6-nitroquinazolin-4(3H)-one, (5.85 g, 61% yield). MS (ESI) m/e (M+H+) 192.0

Provenance & Evidence