Water → HCID 178521752, compound

Participants

Reaction Steps

A solution of 2,2,2-trichloroethyl 2,3-dichlorophenylcarbamate (0.286 g, 0.847 mmol; general method D), 3-(2-fluorophenyl)-1H-pyrazol-5-amine (0.150 g, 0.847 mmol) and I-PR2NET (0.219 g, 1.69 mmol) in DMF (1 mL) was stirred at 90° C. overnight. Water was added (30 mL) and the mixture was extracted with EtOAc (3×30 mL), dried (MgSO4), filtered and concentrated to yield crude 1-(2,3-dichlorophenyl)-3-(3-(2-fluorophenyl)-1H-pyrazol-5-yl)urea as an off-white solid (285 mg, 92% yield). 1H-NMR (DMSO-d6): δ 9.86 (s, 1H), 8.25 (d, 1H, J=7.2 Hz), 7.81 (t, 1H, J=7.2 Hz), 7.45-7.27 (m, 5H), 6.65 (s, br, 1H). 5.67 (s, 1H), one urea proton not visible. LC-MS (EI) m/z: 365.0 367.0 (M+H+).

Provenance & Evidence