Ethyl 4-hydrazinylbenzoate → ethyl 4-[5-amino-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzoate

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Reaction Steps

Using the same method as Example QQ, 4-hydrazinobenzoic acid ethyl ester (From Example A82, 3.0 g, 16.6 mmol) and commercially available 1N NH 4,4,4-trifluoro-3-oxobutyronitrile (3.4 g, 24.9 mmol) were combined to afford ethyl 4-[5-amino-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzoate (4.5 g, 91% yield), which was used to the next reaction without further purification.

Provenance & Evidence