HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile → p-Fluorobenzoylacetonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Benzoic acid, 4-fluoro-, ethyl ester | HCID 67976 | — |
| Product | p-Fluorobenzoylacetonitrile | HCID 2783172 | 86% |
Reaction Steps
Using general method L, ethyl 4-fluorobenzoate (119 g, 0.71 mol) and MeCN (75 mL) were combined to afford 3-(4-fluorophenyl)-3-oxopropionitrile (100 g, 86% yield). 1H NMR (300 MHz, CDCl3): δ 7.98-7.94 (m, 2H), 7.22 (d, J=6.6 Hz, 2H), 4.07 (s, 2H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163756B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-4d20d51479ef48219d584ed932f0c472 |
| Source note | uspto-grants-2012_04 |