Ethyl 2-(4-hydrazinylphenyl)acetate → {4-[5-Amino-3-(4-fluorophenyl)pyrazol-1-yl]phenyl}acetic acid ethyl ester

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Reaction Steps

Using general method M, (4-hydrazinophenyl)acetic acid ethyl ester (36 g, 0.217 mol) and 3-(4-fluorophenyl)-3-oxopropionitrile (38 g, 0.26 mol) were combined to yield {4-[5-amino-3-(4-fluorophenyl)pyrazol-1-yl]phenyl}acetic acid ethyl ester (50 g, 68% yield). 1H NMR (300 MHz, CDCl3): δ 7.80 (s, 2H), 7.40 (m, 4H), 7.00 (m, 2H), 6.29 (s, 1H), 4.07 (q, J=3.9 Hz, 2H), 3.53 (s, 2H), 1.23 (t, J=3.9 Hz, 3H); MS (ESI) m/z: 340 (M+H+).

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