Hydrochloric Acid → HCID 178470365, compound

Participants

Reaction Steps

A solution of 6-tert-butyloxy-9-[5-(5-hydroxy-1H-benzimidazol-2-ylsulfanyl)-furan-2-yl]-8-oxo-2,4,5,7,8,9-hexahydro-pyrrolo[3,4-b]-1,7-naphthyridine-3-carboxylic acid ethyl ester (0.27 g, 0.46 mmol) in dioxane (20 ml) is combined with 4N HCl in dioxane (1.7 ml). The reaction mixture is stirred at room temperature for 16 hours. The formed insoluble material is collected by filtration, washed with dioxane (50 ml), pentane (20 ml), diisopropylether (20 ml) and dried under vacuum to yield 176 mg of 9-[5-(5-hydroxy-1H-benzimidazol-2-ylsulfanyl)-furan-2-yl]-8-oxo-4,5,6,7,8,9-hexahydro-2H-pyrrolo[3,4-b]-1,7-naphthyridine-3-carboxylic acid ethyl ester hydrochloride as a white powder. Yield=73%. Analytical L/MS (method C): m/z=490 (negative ion mode [M−H]−), m/z=492 (positive ion mode [M+H]+).

Provenance & Evidence