Hydrochloric Acid → HCID 178470367, compound

Participants

Reaction Steps

230 mg of 6-tert-butyloxy-9-[5-(5-difluoromethoxy-1H-benzimidazol-2-ylsulfanyl)-furan-2-yl]-8-oxo-2,4,5,7,8,9-hexahydro-pyrrolo[3,4-b]-1,7-naphthyridine-3-carboxylic acid ethyl ester (example 127) are dissolved in 1.4 ml of dioxane and combined with 1.434 ml of 4N HCl in dioxane. The reaction mixture is stirred for 16 hours at room temperature. The formed insoluble material is then collected by filtration, washed successively with 2×2 ml of dioxane and 2×2 ml of diisopropylether, and dried under vacuum to yield 107 mg of 9-[5-(5-difluoromethoxy-1H-benzimidazol-2-ylsulfanyl)-furan-2-yl]-8-oxo-4,5,6,7,8,9-hexahydro-2H-pyrrolo[3,4-b]-1,7-naphthyridine-3-carboxylic acid ethyl ester hydrochloride as a brown powder. Yield=55%. Analytical LC/MS (method B): retention time=2.90 min., m/z=541.96 (positive ion mode).

Provenance & Evidence