Hydrochloric Acid → HCID 178470363, compound

Participants

Reaction Steps

A solution of 6-tert-butyloxy-9-[5-(6-chloro-5-fluoro-1H-benzimidazol-2-ylsulfanyl)-furan-2-yl]-8-oxo-2,4,5,7,8,9-hexahydro-pyrrolo[3,4-b]-1,7-naphthyridine-3-carboxylic acid ethyl ester (0.376 g, 0.60 mmol) in dioxane (20 ml) is combined with 4 N HCl in dioxane (2.17 ml) and the mixture is stirred at room temperature for 16 hours. The formed insoluble material is collected by filtration, washed with dioxane (40 ml), pentane (40 ml), diisopropylether (40 ml) and dried under vacuum to yield 310 mg of 9-[5-(6-chloro-5-fluoro-1H-benzimidazol-2-ylsulfanyl)-furan-2-yl]-8-oxo-4,5,6,7,8,9-hexahydro-2H-pyrrolo[3,4-b]-1,7-naphthyridine-3-carboxylic acid ethyl ester hydrochloride as a light brown powder. Yield=92%. Analytical LC/MS (method B): m/z=528 (positive ion mode, [M+H]+, 1 Cl present), m/z=526 (negative ion mode [M−H]−, 1 Cl present)

Provenance & Evidence