Hydrochloric Acid → HCID 178470360, compound

Participants

Reaction Steps

A solution of 6-tert-butyloxy-9-[5-(5-fluoro-1H-benzimidazol-2-ylsulfanyl)-furan-2-yl]-8-oxo-2,4,5,7,8,9-hexahydro-pyrrolo[3,4-b]-1,7-naphthyridine-3-carboxylic acid ethyl ester (0.380 g, 0.64 mmol) in dioxane (20 ml) is combined with 4 N HCl in dioxane (2.32 ml) and the mixture is stirred at room temperature for 16 hours. The formed insoluble material is collected by filtration, washed with dioxane (40 ml), pentane (40 ml), diisopropylether (40 ml) and dried under vacuum to yield 323 mg of 9-[5-(5-fluoro-1H-benzimidazol-2-ylsulfanyl)-furan-2-yl]-8-oxo-4,5,6,7,8,9-hexahydro-2H-pyrrolo[3,4-b]-1,7-naphthyridine-3-carboxylic acid ethyl ester hydrochloride as a orange-brown powder. Yield=95%. Analytical LC/MS method B: m/z=492 (negative ion mode [M−H]−), m/z=494 (positive ion mode [M+H]+).

Provenance & Evidence