Hydrochloric Acid → HCID 178470369, compound

Participants

Reaction Steps

A solution of 6-tert-butyloxy-8-oxo-9-[5-(5-trifluoromethoxy-1H-benzimidazol-2-ylsulfanyl)-furan-2-yl]-2,4,5,7,8,9-hexahydro-pyrrolo[3,4-b][1,7]naphthyridine-3-carboxylic acid ethyl ester (0.65 g, 0.98 mmol) in dioxane (20 ml) is combined with 4N HCl in dioxane (3.57 ml). The reaction mixture is stirred at room temperature for 16 hours. The formed insoluble material is collected by filtration, washed with dioxane (100 ml), pentane (50 ml) and dried under vacuum to yield 350 mg of 8-oxo-9-[5-(5-trifluoromethoxy-1H-benzimidazol-2-ylsulfanyl)-furan-2-yl]-4,5,6,7,8,9-hexahydro-2H-pyrrolo[3,4-b][1,7]naphthyridine-3-carboxylic acid ethyl ester hydrochloride as a light brown powder. Yield=64%. Analytical LC/MS (method C): m/z=558 (negative ion mode [M−H]−), m/z=560 (positive ion mode [M+H]+).

Provenance & Evidence