Potassium Carbonate → HCID 28351514, compound

Participants

Reaction Steps

(3S)-3-methylpiperidin(S)-(+)-mandelate (19.9 g, 79.1 mmol), 3-bromo-1-propanol (10 g, 71.9 mmol) and potassium carbonate (14.9 g, 108 mmol) were mixed in THF (200 mL), and heated under reflux for 30 hours. The insoluble matter was separated by filtration, the filtrate was concentrated, and ethyl acetate and hexane were added to the residue. The resulting insoluble matter was separated by filtration, the filtrate was concentrated and evaporated under reduced pressure to obtain the intended product (9.6 g, 85%) as a colorless oil. (3S)-3-methylpiperidin (S)-(+)-mandelate was synthesized according to the method described in a reference (J. Org. Chem., 1987, Vol. 52, p. 5466).

Provenance & Evidence