Hydrochloric Acid → HCID 68712747, compound

Participants

Reaction Steps

Dried cesium fluoride (5.31 g, 35.0 mmol) and 3-(methoxymethoxy)pyridine-2-thiol (6.0 g, 35.0 mmol) synthesized in Reference Example 15 were dissolved in DMF (120 mL), and under stirring with cooling with ice, (1R*)-2-{4-[(4-methoxybenzyl)oxy]phenyl}-1-methyl-2-oxoethyl methanesulfonate (11.58 g, 31.8 mmol) synthesized in the above (4) was added. The reaction solution was stirred for 20 hours with cooling with ice, then 2 N HCl (20 mL) and water (180 mL) were added, and further stirred for 20 minutes with cooling with ice. The formed solid was collected by filtration, washed with water, and dried under reduced pressure to obtain the entitled compound (13.3 g, containing 20% side product) as a milky white solid.

Provenance & Evidence