Trifluoroacetic acid → HCID 59396710, compound

Participants

Reaction Steps

The compound synthesized in the above (6) was mixed with anisole (8.52 mL, 78.8 mmol) and trifluoroacetic acid (20 mL, 0.26 mol) under cooling with ice, and stirred for 15 minutes under cooling with ice. Aqueous saturated sodium hydrogencarbonate solution was added, then the reaction solution was extracted with ethyl acetate. The organic layer was washed with aqueous saturated sodium hydrogencarbonate solution, water and saturated saline in that order, and dried with magnesium sulfate. The solvent was removed under reduced pressure, and the residue was purified by silica gel flash column chromatography (hexane/ethyl acetate=1/1), and further recrystallized (ethyl acetate/n-heptane) to obtain the entitled compound (1.9 g, 35% in 2 steps) as a white solid.

Provenance & Evidence