Pyridine → HCID 42629394, compound

Participants

Reaction Conditions

Reaction Steps

4-Chloro-5-(2-methoxy-ethyl)-thiophene-2-sulfonyl chloride (73 mg) was dissolved in acetonitrile (1.5 mL), NaOCN (38 mg) and pyridine (130 mL) was added to the solution. The mixture was stirred for 4 h at 25° C. After that 4-bromo-pyridine-2,6-diamine (50 mg) was added to the mixture as solid. The resulting yellow suspension was stirred for 2 h at 25° C. The suspension was evaporated to dryness, dissolved in DMSO (1.5 mL) and purified with preparative HPLC. N-[(6-amino-4-bromopyridin-2-yl)carbamoyl]-4-chloro-5-(2-methoxyethyl)-thiophene-2-sulfonamide (21 mg, 16.8% yield) was obtained as amorphous white solid.

Provenance & Evidence