HCID 11149071, compound → HCID 67273641, compound

Participants

Reaction Steps

6-(3,4-Dihydro-naphthalen-2-yl)-4-methyl-pyridin-2-ylamine (CAS 521917-11-3) (1.8 g) is dissolved in methanol (30 mL) under an Ar atmosphere. To the obtained solution Pd/C (10%; 250 mg) was added. After that hydrogen was flushed through the reaction mixture (1 bar) for 2 h at 25° C. After that the catalyst was removed by filtration, the filtrate was evaporated to dryness and the crude product was purified by flash chromatography (200 g SiO2, CH2Cl2/1% MeOH) to yield 4-methyl-6-(1,2,3,4-tetrahydro-naphthalen-2-yl)-pyridin-2-ylamine (970 mg) as an oil.

Provenance & Evidence