Ammonia → 6-Bromo-4-methoxypyridin-2-amine

HRID 1696755Notes

Reaction equation

HRID 1696755 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[C:4](Br)[N:3]=1.[NH3:11]>>[Br:1][C:2]1[N:3]=[C:4]([NH2:11])[CH:5]=[C:6]([O:8][CH3:9])[CH:7]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 109015692,6-Dibromo-4-methoxypyridine

Product 1

HCID 714642286-Bromo-4-methoxypyridin-2-amine

Procedure

A solution of 2.00 g 2,6-dibromo-4-methoxy-pyridine in 80 g liquid ammonia under was heated in an autoclave to 140° C. for 4 h. The reaction was cooled to room, evaporated and the residue was purified by silica column chromatography to yield 0.457 g of the title compound as white solid. MS (ISP) M+H+=203.2 205.5

Workup

  1. temperatureThe reaction was cooled to room
  2. customevaporated
  3. customthe residue was purified by silica column chromatography

Sources & evidence

ORD record
ord-0607168f10634fe2bdd63e90859495f7
Source dataset
uspto-grants-2012_04
Patent number
US08163778B2

Reaction notes

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