4-Chlorobenzenesulfonyl isocyanate → HCID 42630231, compound

HRID 1696758Notes

Reaction equation

HRID 1696758 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]=[C:12]=[O:13])(=[O:10])=[O:9])=[CH:4][CH:3]=1.[NH2:14][C:15]1[CH:20]=[C:19]([Br:21])[CH:18]=[CH:17][N:16]=1>C(Cl)Cl>[Br:21][C:19]1[CH:18]=[CH:17][N:16]=[C:15]([NH:14][C:12]([NH:11][S:8]([C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=2)(=[O:9])=[O:10])=[O:13])[CH:20]=1

Participants

4

Reactant 2

HCID 1385874-Chlorobenzenesulfonyl isocyanateHCID 6932822-Amino-4-bromopyridine

Product 1

HCID 42630231HCID 42630231, compoundYield 41.2%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
25 °C

Procedure

4-Chlorbenzenesulfonyl isocyanate (150 mg) was dissolved in CH2Cl2 (2 mL). 2-Amino-4-brompyridine (132 mg) was added to the mixture. After that the mixture was stirred for 18 h at 25° C. The obtained white precipitate was filtered off and washed with CH2Cl2 and dried in vacuo to yield N-[(4-bromopyridin-2-yl)carbamoyl]-4-chlorobenzenesulfonamide (111 mg; 41%) as a white solid.

Workup

  1. filtrationThe obtained white precipitate was filtered off
  2. washwashed with CH2Cl2
  3. customdried in vacuo

Sources & evidence

ORD record
ord-5ed1616470b74e42a7163d073c1e7d0d
Source dataset
uspto-grants-2012_04
Patent number
US08163778B2

Reaction notes

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