Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 1-Benzofuran-3-sulfonyl chloride | HCID 55279079 | — |
| Product | HCID 67273585 | HCID 67273585 | — |
Reaction Steps
To the above prepared benzofuran-3-sulfonyl chloride (0.104 g, 0.480 mmol) was added ammonia (6 eq., 0.5 M in dioxane) and the mixture stirred for one night at 50° C. Evaporation of the solvent, followed by flash chromatography (SiO2, heptane/AcOEt=7/3) and direct crystallization from heptane/AcOEt, generated 0.036 g of the title compound as off-white crystals. Extensive nOE measurements and 13C-NMR NMR corroborated the structure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08163778B2 |
|---|
| Source dataset | uspto-grants-2012_04 |
|---|
| ORD ID | ord-4e90eb14ebec4867a936671f498e51b3 |
|---|
| Source note | uspto-grants-2012_04 |
|---|
