Lithium borohydride → HCID 67274399, compound

Participants

Reaction Steps

To a solution of 0.198 g 6-amino-4-methylsulfanyl-pyridine-2-carboxylic acid methyl ester in 4 ml tetrahydrofuran was added 0.044 g lithiumborohydride and the mixture was stirred at room temperature for 3 h. The reaction mixture was partitioned between ethyl acetate and brine. The phases were separated and the organic phase was purified by chromatography on silica gel with ethyl acetate to ethyl acetate:methanol=9:1. to yield 0.14 g of the title compound as beige crystals. MS (ISP): 171.1 [M+H]+.

Provenance & Evidence