HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1696773Generated: October 31, 2026
Ammonia → 6-Methyl-4-(trifluoromethyl)pyridin-2-amine
https://huagongshe.com/reaction/1696773
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 2-Chloro-6-methyl-4-(trifluoromethyl)pyridine | HCID 2736626 | — |
| Product | Ammonia | HCID 222 | — |
| Product | 6-Methyl-4-(trifluoromethyl)pyridin-2-amine | HCID 18428521 | 189.5% |
Reaction Steps
A mixture of 4.7 g 2-chloro-6-methyl-4-trifluoromethyl-pyridine and 80 g ammonia was heated in an autoclave at 120° C. for 24 h. Ammonia was allowed to evaporate and the residue was purified on silica gel with methylene chloride:methanol:ammonia=9:1:0.1 to yield 4.01 g of the title compound as off white crystals MS (ISP) M+H+=177.1 melting at 53.5-54.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08163778B2 |
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| Source dataset | uspto-grants-2012_04 |
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| ORD ID | ord-0ab8241684f1456b978613145f28a8b1 |
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| Source note | uspto-grants-2012_04 |
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